Chemotactic Cytokines

Author: J. Westwick
Publisher: Springer Science & Business Media
Size: 13.99 MB
Format: PDF, Mobi
Category : Medical
Pages : 180
Chemotactic Cytokines GET EBOOK
The existence of a new family of chemotactic cytokines was realised in 1987 following the isolation and structural determination by several groups of a peptide consisting of 72 amino acids which was a potent activator of neutrophils and a chemotactic agent for lymphocytes. The first symposium of this series was held at the Royal College of Surgeons of England in December 1988, entitled Novel Neutrophil Stimulating Peptides, and brought together the majority of the laboratories which had published in this area, see Immunology Today 10: 146-147(1989). Since the first symposium there has been a dramatic increase in our knowledge of the biology of this family of structurally related peptides. The Second International Symposium on Chemotactic Cytokines was held at the Royal College of Surgeons of England in June 1990. The aim of this symposium was to provide both a forum for discussion and to determine whether this knowledge can be utilised in the design of novel therapeutic strategies for the treatment of inflammatory disorders. Although the majority of studies have been concerned with the regulation of these peptides at the molecular and cellular level, there is now evidence to suggest that specific members of this superfamily have a role in the pathogenesis of a number of diverse diseases including arthritis, psoriasis, atherosclerosis, wound repair, inflammatory lung diseases and glomerulonephritis.
RELATED BOOKS
Interleukin-8 (NAP-1) and Related Chemotactic Cytokines
Language: en
Pages: 163
Authors: Marco Baggiolini, Clemens Sorg
Categories: Medical
Type: BOOK - Published: 1992 - Publisher: Karger Medical and Scientific Publishers

Books about Interleukin-8 (NAP-1) and Related Chemotactic Cytokines
Chemotactic Cytokines
Language: en
Pages: 180
Authors: J. Westwick, I.J.D. Lindley, S.L. Kunkel
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

The existence of a new family of chemotactic cytokines was realised in 1987 following the isolation and structural determination by several groups of a peptide consisting of 72 amino acids which was a potent activator of neutrophils and a chemotactic agent for lymphocytes. The first symposium of this series was held at the Royal College of Surgeons of England in December 1988, entitled Novel Neutrophil Stimulating Peptides, and brought together the majority of the laboratories which had published in this area, see Immunology Today 10: 146-147(1989). Since the first symposium there has been a dramatic increase in our knowledge of the biology of this family of structurally related peptides. The Second International Symposium on Chemotactic Cytokines was held at the Royal College of Surgeons of England in June 1990. The aim of this symposium was to provide both a forum for discussion and to determine whether this knowledge can be utilised in the design of novel therapeutic strategies for the treatment of inflammatory disorders. Although the majority of studies have been concerned with the regulation of these peptides at the molecular and cellular level, there is now evidence to suggest that specific members of this superfamily have a role in the pathogenesis of a number of diverse diseases including arthritis, psoriasis, atherosclerosis, wound repair, inflammatory lung diseases and glomerulonephritis.
Cytokines
Language: en
Pages: 584
Authors: Anthony R. Mire-Sluis, Robin Thorpe
Categories: Medical
Type: BOOK - Published: 1998-04-15 - Publisher: Academic Press

This book provides comprehensive coverage of the cytokines from a pharmacological approach. The chapters are presented in a consistent format allowing easy cross-reference, with sample diagrams and a summary table of essential facts for each chapter at the end of the book. Cytokines is unique in stressing cytokine biology and the application of research data to provide disease therapy. With 33 detailed and up-to-date chapters about individual cytokines, this comprehensive reference will provide both clinicians and researchers in immunology and pharmacology with invaluable information. Genetic information and sequences Protein structure Cell sources and production Biological activity Cytokine receptor structure and signal transduction Discussion of the role of cytokines in disease and the potential for therapy Summary table of essential facts Comprehensive bibliography
Chemoattractant Ligands and Their Receptors
Language: en
Pages: 400
Authors: Richard Horuk
Categories: Medical
Type: BOOK - Published: 2020-01-31 - Publisher: CRC Press

Chemoattractant Ligands and Their Receptors succinctly summarizes cutting-edge research in the important area of chemoattraction in immunology. It explains how chemoattractant molecules mobilize immune cells to ward off attack by invading pathogens, both at a molecular and at a cellular level. Written by acknowledged experts in the field, it contains detailed molecular and structural information on each of the major chemoattractants and their receptors. Its unique multidisciplinary approach encompasses biology, immunology, protein chemistry, and molecular biology. A time-saving reference for both researchers and students.
Dictionary of Cytokines
Language: en
Pages: 778
Authors: Horst Ibelgaufts
Categories: Science
Type: BOOK - Published: 1995 - Publisher: Wiley-Blackwell

The Dictionary of Cytokines provides concise yet comprehensive coverage of such diverse topics as - alternative nomenclature, - sources and targets of cytokines, - protein characteristics, - gene organization and chromosomal location, - related factors and factor families, - receptor structure and expression, - biological activities in vitro and in vivo, - assay systems, - cytokine studies in transgenic animal models. This 800+ page dictionary comprises ca. 3200 extensively cross- referenced entries, ca. 14000 primary references and reviews, and more than 100 full color illustrations. It guides the user through the zoo of factors, the jungle of interactions, the morasses of acronyms, and the desert of synonyms. The book will be an invaluable aid for the growing number of clinicians, scientists and advanced students of immunology, hematology, oncology, endocrinology, biochemistry, cell biology and molecular biology confronted with the necessity of coming to terms with this key area of interdisciplinary research.
Medical Subject Headings
Language: en
Pages:
Authors: National Library of Medicine (U.S.)
Categories: Index medicus
Type: BOOK - Published: 1999 - Publisher:

Books about Medical Subject Headings
The Chemokines
Language: en
Pages: 227
Authors: I.J.D. Lindley, J. Westwick, S. Kunkel
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

The first symposium in this series was held at the Royal College of Surgeons of England in December 1988 and was entitled "Novel Neutrophil Stimulating Peptides". That symposium successfully brought together the majority of laboratories working in the area of interleukin-8 and related peptides; see Immunology Today 10: 146-147 (1989). The Second International Symposium on Chemotactic Cytokines was held at the same venue in June 1990, and a much-increased attendance reflected the accelerating pace of work in the area of these chemotactic cytokines. The proceedings of that meeting were published in Advances in Experimental Medicine and Biology, vol. 305 (1991). The rapid advances made in the field of chemotactic cytokines over the last 18 months necessitated a third Symposium in this series to collate and place in perspective an explosion of new data. The Third International Symposium on Chemotactic Cytokines was held between August 31 and September 1, 1992 in Baden-bei-Wien, Austria. However, the lack of a clear nomenclature system was creating some confusion in the area, especially as new factors continue to be discovered and classified as family members. In the past, these inflammatory mediators had been placed arbitrarily under the broad heading of "intercrines" or "chemotactic cytokines" with no clear classification guidelines to follow. This nomenclature issue was addressed at the Symposium, where investigators in the field were invited to reach a consensus regarding a collective name for these mediators. The resulting decision was to identify the major family as chemokines, to replace all previous terms.
Cytokines of the Lung
Language: en
Pages: 664
Authors: J. Kelley
Categories: Medical
Type: BOOK - Published: 2022-04-19 - Publisher: CRC Press

Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book supplies information on amino acid structure and gene regulatory sequences, examines the receptor biology of individual cytokines, illustrates cytokine interactions with their cognate receptors and surveys the phenotypic effects of individual cytokines on target cells. With over 2700 literature citations and figures, this book is a resource for pulmonologists, physiologists, immunologists, cell and molecular biologists, environmental toxicologists, oncologists, and graduate-level and medical school students in these disciplines.
Cytokines and Cytokine Receptors
Language: en
Pages: 592
Authors: Constantin A. Bona, Jean-Pierre Revillard
Categories: Science
Type: BOOK - Published: 2001-03-07 - Publisher: CRC Press

The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic
History of Chemoattractant Research
Language: en
Pages:
Authors: Bernhard Moser
Categories: Science
Type: BOOK - Published: 2016-01-07 - Publisher: Frontiers Media SA

In the Research Topic "History of Chemoattractant Research" we will portray some of the key discoveries that helped to transform cell migration research into a global playing field within immunology (and beyond). Early progress had a profound effect on both, academia and industry. Today, numerous academic laboratories are fully engaged in compiling a detailed road map describing the highly complex network of immune and tissue cells that respond to chemoattractants. Industrial research, on the other hand, centers on drugs that interfere with immune cell traffic in inflammatory diseases and cancer. The following series of “short stories” provide personal accounts on key discoveries. The individual molecular discoveries enabled numerous research laboratories worldwide to unravel their significance in steady-state or pathological immune processes. Although ground-breaking in their own right, it is therefore worth emphasizing that rapid progress in chemoattractant research was made possible by many other laboratories who were not directly involved in the original discovery process. Therefore, the authors of this mini-series are discussing their findings in the context of time, place and subsequent progress enabled by their discoveries. It is hoped that a wide readership will find these accounts entertaining as well as educational although those who wish to gain a more detailed knowledge are referred to the many outstanding reviews on chemokines and other chemoattractants.
National Library of Medicine Current Catalog
Language: en
Pages:
Authors: National Library of Medicine (U.S.)
Categories: Medicine
Type: BOOK - Published: 1992 - Publisher:

Books about National Library of Medicine Current Catalog
Cytokines in Animal Health and Disease
Language: en
Pages: 480
Authors: Michael J. Myers
Categories: Nature
Type: BOOK - Published: 1995-06-09 - Publisher: CRC Press

This work offers comprehensive, up-to-date coverage of cytokine biology in veterinary and agricultural species, describing the role of cytokines in physiological and pathological processes. It addresses recent advances and new information on the function of cytokines in reproduction, detoxification of xenobiotics, growth modulation and other areas, and discusses the approaches to and pitfalls of studying cytokines in animals.